With the prevalence of health screening, more patients are diagnosed at a relatively early stage with less invasion depth. In 2018, more than seven hundred thousand people were diagnosed with rectal cancer (RC), and the overall mortality rate was 44.1%.
A preoperative NLR of more than 2.8 is an independent prognostic factor for poor DFS in T1–2 RC patients.Ĭolorectal cancer (CRC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. NLR, PLR, and PNI are valuable factors for predicting postoperative complications in T1–2 RC patients. On multivariate analysis, only high NLR was identified as an independent risk factor for poor DFS. Patients with high NLR/PLR or low LMR/PNI had lower OS and DFS rates. In addition, high NLR, high PLR, and low PNI were correlated with an increased postoperative morbidity rate. Significant but heterogeneous associations were found between NLR, PLR, LMR and PNI and clinicopathological factors. The optimal cut-off values for preoperative NLR, PLR, LMR and PNI were 2.8, 140.0, 3.9, and 47.1, respectively. The relationships of these parameters with postoperative morbidities and prognosis were statistically analysed. The cut-off values for NLR, PLR, LMR, and PNI were determined by receiver operating characteristic curves. MethodsĬlinical data of 154 T1–2 RC patients were retrospectively reviewed. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and prognostic nutritional index (PNI), remains controversial in T1–2 rectal cancer (RC).
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